Nicotine poisoning

Definition

Nicotine is a bitter-tasting compound that naturally occurs in large amounts in the leaves of tobacco plants.

Nicotine poisoning results from taking too much nicotine. Acute nicotine poisoning usually occurs in young children who accidentally chew on nicotine gum or patches. Nicotine is rapidly absorbed after ingestion and inhalation. In young children, ingestion of 1 to 2 mg of nicotine has been associated with signs of toxicity (poisoning).

This article is for information only. DO NOT use it to treat or manage an actual poison exposure. If you or someone you are with has an exposure, call the local emergency number (such as 911), or the local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States.

Poisonous Ingredient

Nicotine

Where Found

Nicotine is found in:

  • Chewing tobacco
  • Cigarettes
  • E-cigarettes
  • Liquid nicotine
  • Nicotine gum (Nicorette)
  • Nicotine inhalers (Nicorette)
  • Nicotine patches (Habitrol, Nicoderm)
  • Pipe tobacco
  • Some insecticides
  • Tobacco leaves

Note: This list may not be all inclusive.

Symptoms

Symptoms of nicotine poisoning include:

  • Abdominal cramps
  • Agitation, restlessness, excitement, or confusion
  • Breathing that may be difficult, rapid, or even stopped
  • Burning sensation in mouth, drooling
  • Seizures
  • Depression
  • Fainting or even coma (lack of responsiveness)
  • Headache
  • Muscle twitching and damage
  • Palpitations (fast and pounding heartbeat often followed by slow heart rate)
  • Vomiting
  • Weakness

Home Care

Seek immediate medical help. DO NOT make a person throw up unless told to do so by poison control or a health care professional.

If the chemical is on the skin, wash with soap and lots of water for at least 15 minutes.

Before Calling Emergency

Determine the following information:

  • The person's age, weight, and condition
  • Name of product (as well as the ingredients and strength, if known)
  • When it was swallowed or inhaled
  • The amount swallowed or inhaled

However, DO NOT delay calling for help if this information is not immediately available.

Poison Control

The local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.

You can also get online poison help now at Poisonhelp.org. Just enter the product, poison, or medicine to get expert help.

For more information about America's Poison centers, go to poisoncenters.org/.
 

What to Expect at the Emergency Room

If you go to the emergency room, take the container with you, if possible.

The health care provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure. Symptoms will be treated as appropriate. The person may receive:

  • Activated charcoal
  • Airway support, including oxygen, breathing tube through the mouth (intubation), and breathing machine (ventilator)
  • Blood and urine tests
  • Chest x-ray
  • ECG (electrocardiogram, or heart tracing)
  • Fluids through a vein (IV)
  • Laxative
  • Medicines to treat symptoms, including agitation, rapid heart rate, seizures, and nausea

Outlook (Prognosis)

How well a person does depends on the amount of poison swallowed and how quickly treatment was received. The faster a person gets medical help, the better the chance for recovery.

A nicotine overdose may cause seizures or death. However, unless there are complications, long-term effects from nicotine overdose are uncommon.

References

Aronson JK. Nicotine and nicotine replacement therapy. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Philadelphia, PA: Elsevier; 2016: pp.151-156.

Breuner CC. Substance use disorder. In: Kliegman RM, St. Geme JW, Blum NJ, et al, eds. Nelson Textbook of Pediatrics. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 157.

Chary MA, Erickson TB. Cocaine and other sympathomimetics. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 144.

Nelson LS, Calello DP. Acute poisoning. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 96.

Theobald JL, Corcoran JN. Poisoning. In: Kliegman RM, St. Geme JW, Blum NJ, et al, eds. Nelson Textbook of Pediatrics. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 94.

Review Date: 1/8/2025
Reviewed By: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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